In this chapter, Voltaire discusses the expedition of Christopher Columbus, highlighting the challenges of securing sponsorships, including failed attempts in England, Portugal and France, before finally gaining support from Spain under Queen Isabella I of Castile. The chapter details Columbus’ discovery of the Santo Domingo Islands, the Caribbean, and Jamaica, amongst others, and explores his resourcefulness in addressing the scepticism and jealousy of his critics. Voltaire also discusses Amerigo Vespucci and his expeditions, as well as the indigenous peoples of the Americas, their physical characteristics, customs, and interactions with the Spaniards. The chapter concludes with a discussion of America’s flora and fauna, as well as the Columbian Exchange, the laws regulating Spanish trade and the disadvantages of the Columbian expeditions, including Spanish emigration driven by colonisation and the spread of infections, to mention a few.